2'-Ribose-modified nucleotides: A strategy for reducing off-target effects of oligonucleotide drugs.

Mol Ther Nucleic Acids · 2026 · PMC12870468 · PMID 41646886

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highly significantno p-value reported

Notably, siRNA-4 demonstrates a 21.5-fold reduction in IC 50 value compared to the parent, indicating a highly significant inhibitory effect.

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