A Statistical Framework for Measuring Reproducibility and Replicability of High-Throughput Experiments From Multiple Sources.

Stat Med · 2026 · PMC12871010 · PMID 41636474

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hedged sentence

1.0000

closest p · 20.0× alpha

1.0000

boldest claim

The sentences

highly significantp < 1not close (p > 0.1)

As shown in Figure 5A , both sets have similar FIMO score ranges, but the nestedIDR‐specific set contains a higher proportion of peaks with highly significant FIMO matches (e.g., 39.52% of nestedIDR‐specific peaks have p < 1 0 − 6 , vs. 30.70% in the IDR‐specific set), suggesting stronger biological relevance.

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