Magnesium-doped bioactive glass enhances bone regeneration by reversing replicative senescence of human dental pulp stem cells in bone defect therapy.

Regen Biomater · 2026 · PMC12872399 · PMID 41660064

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a decreasing trendno p-value reported

The mRNA expression of IKKα and IKKγ also showed a decreasing trend in the 20 Mg-BG group.

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an increasing trendno p-value reported

The qRT-PCR data indicated that, compared to the P10 Os group, the 20 Mg-BG group significantly upregulated COL1 mRNA expression in replicatively senescent hDPSCs, while the mRNA levels of OCN and RUNX2 showed an increasing trend ( Figure 5E ).

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