MicroRNA profiling in post-mortem spinal cord of C9ORF72-related ALS patients reveals molecular pathways involved in motor neuron degeneration.

Front Neurosci · 2026 · PMC12876226 · PMID 41658940

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an increasing trendno p-value reported

Moreover, SOX2 expression showed an increasing trend in C9ORF72-related ALS tissues compared to healthy controls, suggesting the activation of a compensatory, pro-survival response in an attempt to preserve motor neuron integrity.

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