A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.

Cancer Discov · 2026 · PMC12877754 · PMID 41128661

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highly significantno p-value reported

Inference of TF binding in these regions based on the algorithm MEME ( 43 ) showed highly significant enrichment in members of FOS (FOS, FOSB, FOSL1, and FOSL2) and JUN (JUN, JUNB, and JUND) family of TFs ( Fig. 5B ).

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