Therapeutic efficacy of extracellular vesicles from hiPSC-derived MSCs in serum-containing and xeno-free media for osteoarthritis treatment.

Stem Cell Res Ther · 2026 · PMC12879422 · PMID 41652460

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0700

boldest claim

The sentences

highly significantP = 1 × 10−4actually significant

This showed that treatment with both hiEV preparations exerted strong and highly significant reductions in trabecular bone volume fraction compared with untreated DMM joints (BV/TV% hiEV_serum: Beta = − 12.84, P = 1 × 10−4; hiEV_PS: Beta = − 9.94, P = 3.93 × 10−4).

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a slight trendP = 7.0 × 10− 2so close (0.05 < p ≤ 0.1)

Again, although hydrogel alone showed a slight trend towards improved Col2 expression this was not significant (Beta = 0.53, P = 7.0 × 10− 2 ).

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