Hepatorenal vulnerability flagged by glomerular hyperfiltration in metabolic liver disease: a large health-screening cohort evidence.

Diabetol Metab Syndr · 2026 · PMC12879431 · PMID 41514288

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a decreasing trendno p-value reported

Regardless of sex, the hyperfiltration cutoff values showed a decreasing trend with increasing age, which is consistent with our previous study [ 6 ].

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a slightly increasing trendno p-value reported

Secondary outcome Regardless of the presence of MASLD (or MAFLD), the presence of GHF itself showed a slightly increasing trend in the risk of advanced liver fibrosis with statistical significance (HR: 1.09, 95% CI 1.04–1.14) even after adjustment with metabolic liver disease (Table 2 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.