In tests for effect modification between the APOE-e4 allele and plasma homocysteine, folate, B6, and B12 with both outcomes of total cognitive function and longitudinal total cognitive decline, we found no significant interactions (p-value range from 0.12-0.94), with only a trend towards significance detected between B6 and e4 allele for baseline total cognitive function (p=0.12).
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Do the effects of APOE-ε4 on cognitive function and decline depend upon vitamin status? MacArthur Studies of Successful Aging.
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