NSD2 upregulation is driven by high-risk HPV E6/E7 and disrupts epithelial differentiation in HPV-associated head and neck cancer.

J Exp Clin Cancer Res · 2026 · PMC12882316 · PMID 41507992

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In addition to that, E6/E7 also decreased H3K27me3 levels (although only near to significance), as observed in HNSCC cell lines, and induced the downregulation of H3K20me3 and the upregulation of H4K20me1 (Fig. 1 C).

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