While four mouse models, namely App NL−F , APP23, ARTE10, and tg-APP Swe , have been reported to predominantly harbor Type II Aβ fibrils in their brains [ 7 , 15 ], the inclusion of the 5xFAD and App NL−F Psen1 P117L models in this category remains highly significant.
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The molecular fidelity of Aβ pathology in 5xFAD and App<sup>NL-F</sup>Psen1<sup>P117L</sup> mice revealed by cryo-EM.
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