Association of PD-1<sup>+</sup> B cells and IgG<sup>+</sup> plasma cells with clinical cure of hepatitis B following interferon therapy.

During PEG-IFN therapy, the C group showed an increasing trend, whereas the NC group remained relatively stable.

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Dynamics of PD-1+ B cell subset frequencies in IHCs following PEG-IFN therapy The frequencies of PD-1+ memory B cells, plasmablasts, naïve B cells, and total B cells in IHCs exhibited a decreasing trend following PEG-IFN therapy; however, none of these changes reached statistical significance.

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