Efficacy of dual HER2 blockade in neoadjuvant HER2-positive breast cancer: a meta-analysis of RCTs.

Syst Rev · 2026 · PMC12882624 · PMID 41508104

Europe PMC DOI

hedged sentences

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

a numerical trendp = 0.09so close (0.05 < p ≤ 0.1)

The P + H arm showed a numerical trend without reaching statistical significance in 5-year DFS rate, compared to the H arm (RR 1.09, 95% CI 0.99–1.20, p = 0.09; Fig. 7 ).

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a positive trendno p-value reported

The 5-year OS rates were 93.9% and 90.0% respectively, with a positive trend towards the P + H arm (HR 0.53; 95% CI 0.23–1.19).

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