Early postoperative pain and opioid use after liver surgery: A systematic review and meta-analysis.

J Int Med Res · 2026 · PMC12883716 · PMID 41655272

Europe PMC DOI

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0.2400

closest p · 4.8× alpha

0.2400

boldest claim

The sentences

a nonsignificant trendp = 0.24not close (p > 0.1)

ITM dose (continuous) explained 13% of the between-study variance (R 2 = 13.3%), with a nonsignificant trend toward diminishing analgesic benefit at higher doses (β = −2.48 SMD per mg; 95% CI: −6.61 to +1.64; p = 0.24).

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