Deciphering miRNA-mediated genetic architecture of immune cell subsets in hypertrophic scars and keloids: A 2-step Mendelian randomization study unveiling causal associations.

Medicine (Baltimore) · 2026 · PMC12885672 · PMID 41650060

Europe PMC DOI

hedged sentences

0.0470

closest p · 0.9× alpha

0.0470

boldest claim

The sentences

marginally significantP = .047actually significant

Notably, miR-6887-5p exhibited a total effect on keloid formation risk (β = 0.324, 95% confidence interval [CI]: 0.073–0.576) and a direct effect (β = 0.283, 95% CI: 0.027, 0.538), with a marginally significant mediation effect through B-cell activating factor receptor on CD20− CD38− B cells (β = 0.042, 95% CI: −0.001, 0.084, P = .047).

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highly significantno p-value reported

Several of these associations were highly significant, with P -values well below the .05 threshold.

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