The efficacy of artesunate in animal models of sepsis: a systematic review and meta-analysis.

Given its marginal significance and to preclude any potential bias, a trim-and-fill analysis was conducted.

also in 5,069 other papers

This analysis imputed two missing studies, and the adjusted effect size (HR = 1.646) was nearly identical to the original (HR = 1.807) and remained highly significant ( Table 3 ), indicating that the primary survival outcome is relatively robust despite the inability to rule out publication bias.

also in 132,142 other papers