Development of a green chemistry based bioanalytical method using response surface methodology to analyze febuxostat and indomethacin in rabbit plasma.

Design of experiment Table 3 presents The Design of Experiments (DoE) analysis revealed that, for FEB, the most significant factors influencing resolution were A, B, and the quadratic term A2, each with highly significant p-values (all below 0.01), while other factor combinations such as C, AB, AC, BC, B2, and C2 had no meaningful impact (all p-values above 0.2).

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