Barely Significant
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The global, regional, and national burden of non-rheumatic degenerative mitral valve disease from 1990 to 2021 and forecast for 2050.

Front Cardiovasc Med · 2026 · PMC12892346 · PMID 41685179

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a decreasing trendno p-value reported
Similarly, the ASDALYR showed a decreasing trend [EAPC, −1.32 (95% CI, −1.41–−1.22)].

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