The temporal and stimuli-specific effects of LPS and IFNγ on microglial activation.

Cellular levels of OPN as well as SPP1 gene expression increased only in the LPS group ( Figure 4I ; Supplementary Figure 3A ) while all other groups showed a decreasing trend over time.

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However, an increasing trend was observed over time, which became significant for LPS- and LPS/IFNγ-treated hiMG, except for IFNγ-treated hiMG in which the Galectin-3 levels were lower than in controls ( Figure 4F ).

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