Colorectal cancer-derived osteopontin rewires macrophages into a pro-metastatic M2 state via the PI3K/AKT/CSF1-CSF1R axis.

Cell Death Discov · 2026 · PMC12894849 · PMID 41639044

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a slight trendno p-value reported

Additionally, transwell invasion and migration assays revealed that OPN expression levels did not influence the invasion or migration of CRC cells, although there was a slight trend toward the opposite effect (Fig. 3C ).

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