Unraveling the Cross-Tissue Neuroimmune-Vascular Genetic Architecture of Migraine Using Integrated Multi-Omics, Single-Cell, and Spatial Transcriptomics: Prioritizing T-Cell Regulatory Networks and Peripheral Targets.

Overall, results show that the trait’s genetic basis consists, on one hand, of a few highly significant, chromosome-specific clustered main-effect loci and, on the other hand, of latent secondary independent signals in several key loci revealed only by conditional analysis, reflecting a multi-level and regionally varying genetic structure. 3.

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