A broad-spectrum SARS-CoV-2 RBD vaccine with selected high-impact mutations and novel adjuvant induces durable T cell response and broad protection in mice.

the viral titers in the lung tissues of the control group mice displayed a decreasing trend from 4 dpi (with an average of 5.6 log 10 E gene copies/mg) to 9 dpi (with an average of approximately 4.4 log 10 E gene copies/mg), while viral loads in the nasal turbinates and brains gradually increased ( Figure 5D ).

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