Preclinical pharmacokinetics and tissue distribution of a polyhexamethylene guanidine derivative after ocular mucosal administration.

In parallel, the dose-independent parameters remained relatively invariant across the dosing range: 1) The elimination t1/2 remained stable across doses (range: 1681.6–1732.6 min); 2) The apparent clearance normalized to body weight (CL, ml/min/kg) showed only minor variability; 3) The V d demonstrated a decreasing trend but remained within the expected range with overlapping standard deviations.

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