Evolutionary Transitions in Social Behavior are Associated With Convergent and Partially Reversible Expansions of Transcription Factor Binding Sites.

Interestingly, four social consistent OGs, homeobox protein ARX, mitochondrial transcription factor A (TFAM), myoneurin, and LOC102655824 (uncharacterized) , are annotated with the “DNA binding” GO term (GO:0003677), a marginally significant enrichment relative to expectations based upon the number of total OGs annotated with DNA binding (2.7-fold enrichment; P = 5.57e−2, hypergeometric test of overlap) ( Table S14 ).

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