Taiyintiaowei-Tang ameliorates hepatic steatosis of mice fed with acute high-fat diet plus alcohol binge by blockade of NLRP3 inflammasome.

32 In addition, obesity is a highly significant factor in promoting the process of AFLD, alcohol-related liver disease may be more likely to occur in the presence of obesity, and obese populations are more likely to develop liver injury if they consume alcohol. 33 , 34 According to clinical studies, the incidence of liver lesions is higher after simultaneous intake of HFD and high amounts of alcohol.

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In addition, tissue immunofluorescence results showed that the expression of Caspase-1 and Asc in mice livers of HFD plus alcohol binge group showed an increasing trend compared with the normal group, while TYTWT reduced their expression in a dose-dependent manner with the most effective dose at 200 mg/kg ( Fig. 3 E and F).

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