Synthesis, characterization, and <i>in silico</i> and <i>in vivo</i> profiling of selective cyclo-oxygenase-2 inhibitors of indazole-indolinone derivatives with anti-inflammatory and analgesic potency.

The values of the groups are represented as mean ± SEM; with values less than or equal to 0.05 considered statistically significant and those less than or equal to 0.01 considered highly significant ( Festing, 2002 ; Gosselin, 2018 ). 2.5 Ethical approval Prior to the in vivo experimentation, the proposal was submitted to the institutional ethical committee describing in detail the purpose and rationale of performing the experiments on the animal models, and the animal experiments were started

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