Origin dictates function: The dual roles of exosomes derived from diverse origins in the onset and progression of colorectal cancer (Review).

Notably, epidemiological studies have revealed an increasing trend in CRC incidence and mortality among younger populations, statistical projections indicate that by 2030, ~33% of colorectal cancer cases will occur in individuals <50 years of age ( 3 – 5 ), which is mainly associated with changes in dietary habits, environmental factors and unhealthy lifestyle choices, such as smoking, alcohol consumption and lack of exercise ( 6 – 9 ).

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