Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare SORL1 variants.

Upon correlating CSF‐sSORL1 across the union of AD cases and controls who were SORL1 WT, we observed only a weak trend for an (unexpected) positive association with CSF‐Aβ42 concentrations ( p = 0.022), and while the correlation with pTau‐181 was weaker than when conditioning on AD patients only, it remained significant ( p = 3.1 × 10 −3 ) (Figure S12 ). 4.

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