In Setd8 cKO retinas, the percentage of EdU+ cells among YFP+ cells showed a decreasing trend at P0 ( Figures 4 A–4C) and became significantly lower at P2 ( Figures 4 D–4F), indicating that Setd8 is essential for maintaining RPC proliferation.
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Histone methyltransferase Setd8 preserves chromatin accessibility to safeguard retinal progenitor cell identity during development.
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