Leveraging ancestral recombination graphs for scalable mixed-model analysis of complex traits.

Among the highly significant genes detected using ARG-RHE, SYNE1 has a reported association with Lp(a) levels in the Hutterites, a founder population of South Dakota. 60 Associations with ESR1 have been reported in Klos et al., 61 and the RGS17 gene was significantly associated using exome sequencing data. 59 Other signals uniquely identified using ARG-RHE in our analyses and not reported in Open Targets include loci previously linked to traits that are related to those we have found to be associated.

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