(Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #1: This is a high-quality methodological study that provides important quantitative evidence and practical design recommendations for an under-researched yet practically significant issue in small-sample clinical trials, such as those for rare diseases: the impact of allocation bias on stratified analysis with multi-component endpoints.
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Assessing allocation bias in stratified clinical trials with multi-component endpoints evaluated using the stratified Wei-Lachin test.
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