Barely Significant
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CCL14, identified by multi-omics approach, serves as a novel indicator of disease severity and progression in lymphangioleiomyomatosis.

Orphanet J Rare Dis · 2026 · PMC12905834 · PMID 41559739

Europe PMCDOI
1
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0.1028
closest p · 2.1× alpha
0.1028
boldest claim

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a positive trendp = 0.1028not close (p > 0.1)
Additionally, scRNA-seq analysis of six LAM patients revealed that the proportion of CCL14+ endothelial cells (ECs) within the endothelial compartment exhibited a statistically significant positive correlation with the expression of inflammatory gene sets in immune cells ( r = 0.9429, p = 0.0127) and a positive trend with the expression of metastasis-associated gene signatures in LAM cells ( r = 0.7714, p = 0.1028) and T cell inhibitory signatures ( r = 0.7714, p = 0.1028) (Fig. 3 F–H).

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