SETDB1 enables development beyond cleavage stages by extinguishing the MERVL-driven two-cell totipotency transcriptional program in the mouse embryo.

Elife · 2026 · PMC12908936 · PMID 41697236

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highly significantno p-value reported

We found highly significant overlap between proximal MT2-controlled DEGs and DEGs downregulated in 2cWT vs. 2cKO (p adj=3.19E–04); proximal MT2-controlled DEGs and DEGs in 8cWT vs. 8cKO (p adj=7.17E–04); E2c MT2i-downregulated genes and SETDB1-repressed DEGs at 2c (p adj=8.18E–05); and E2c MT2i-downregulated genes and SETDB1-repressed DEGs at 8c (p adj=5.77E–11).

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