Puerarin's multidimensional antidepressant action: decoding the gut-liver-brain axis through gut microbiota, hepatic homeostasis, and neuroimmune regulation.

Front Neurosci · 2026 · PMC12909541 · PMID 41710157

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an increasing trendno p-value reported

According to the World Health Organization (WHO), more than 300 million people around the world are suffering from depression, and the number of patients with depression increased by 18.4% from 2005 to 2015, and the data of this type of common mental disorders show an increasing trend ( World Health Organization, 2017 ).

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