Epidemiological Shifts in Visceral Leishmaniasis Incidence, Relapse, and Mortality in Brazil, 2007-2023: Analysis Using the National Notifiable Diseases Information System.

This reflects the changes in national guidelines that gradually expanded the indications for L-AmB, including not only for the patients with restrictions on antimonial use, but also cases meeting severity criteria and subgroups with a recognized poorer prognosis, such as the extremes of age and immunocompromised patients, marking a positive trend toward safer and more effective therapies ( Table 1 ) [ 10 ].

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