Epigenetic alterations of AKT1 orchestrate a metabolic reprogramming in advanced lipedema: translational insights from an integrated multi-omics study.

J Transl Med · 2026 · PMC12911300 · PMID 41580786

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highly significantno p-value reported

This focused subset yielded a highly significant enrichment of metabolic and mitochondrial programs, including metabolism, aerobic respiration and respiratory electron transport and additional pathways related to mitochondrial protein turnover and Complex IV assembly (Supplementary Figure S5 ).

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