Integrative CRISPR Screening and RNA Analyses Discover an Essential Role for PUF60 Interactions with 3' Splice Sites in Cancer Progression.

There is no consensus motif known to influence PUF60’s selection of PPTs and, although they are typically U-rich without a strict consensus ( 47 ), motif analysis revealed a highly significant alternating UC residue, suggesting a strong preference at PPTs containing a UCUCUCUC motif ( Fig. 2C ).

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