highly significantp < 0.001
Statistical significance was defined as follows: p < 0.05 (*), statistically significant; p < 0.01 (**), highly significant; p < 0.001 (***) extremely significant.
Statistical significance was defined as follows: p < 0.05 (*), statistically significant; p < 0.01 (**), highly significant; p < 0.001 (***) extremely significant.