Impaired excitability of fast-spiking neurons in a novel mouse model of <i>KCNC1</i> epileptic encephalopathy.

Such experiments support a highly significant and robust difference in our (albeit imperfect) measurement of the membrane:cytosol ratio of Kv3.1 immunofluorescence between WT and Kcnc1-A421V/+ mice, which is consistent with lack of membrane trafficking (Figure 3).

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