Interrelations between dopaminergic-, gabaergic- and glutamatergic neurotransmitters in antipsychotic-naïve psychosis patients and the association to initial treatment response.

Using the 4 P model, we found highly significant associations between k 3 estimates in nucleus accumbens (NAcc) and psychotic symptoms at baseline as well as between k 3 and the effect of six weeks of treatment with the partial D 2 receptor agonist aripiprazole, whereas no associations were found with the TR-method [ 11 ].

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