Multi-scale systems toxicology defines a KLF5-centered adverse outcome pathway linking DEHP exposure to pancreatic cancer progression and signaling programs relevant to therapy tolerance.

Front Cell Dev Biol · 2026 · PMC12917211 · PMID 41727317

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borderline significanceno p-value reported

We acknowledge the borderline significance and have provided detailed instrument strength (F-statistics) in Supplementary Table S8 to support the robustness of these preliminary causal inferences.

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