Production of a risk mitigation matrix and four-grade threshold scale using Cox Regression to predict osteoarthritis development.

Key findings The analysis revealed statistically significant relationships between biomarker concentrations and OA risk, with IL-6 [X 2 [ 71 ] = 268.287, p < 0.001], TNF-α [X 2 [ 71 ] = 319.823, p < 0.001] and MPO [X 2 [ 71 ] = 422.943, p < 0.001] showing highly significant negative regression coefficients ( Table 1 , Figures 1 , 2 , and 3 ) [ 48 ], 70 ].

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