Efficacy and safety of single-dose oral postoperative medications in reducing pain after endodontic treatment: a systematic review and meta-analysis.

BMC Oral Health · 2026 · PMC12918069 · PMID 41588508

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did not achieve significanceno p-value reported

Tramadol and ibuprofen showed smaller yet statistically significant effects, while ibuprofen + alprazolam did not achieve significance (MD: −1.75; 95% CI: −3.56 to 0.07).

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