L-kynurenine reshapes immune microenvironment to alleviate methamphetamine-induced chronic lung injury through gut-lung axis.

Compared with the MA-treated AEC group, the protein expression of E-cadherin and ZO-1 was significantly increased, and the protein expression of Vimentin showed a decreasing trend in the co-culture of MA-treated AEC and L-KYN-stimulated differentiated Treg cells for 24 h ( P = 0.0224; P = 0.0002; P = 0.0332; Fig. 8 C–F).

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