Barely Significant
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Caution over haste: why novel endocrine therapy in early lines should wait in Estrogen receptor positive human epidermal growth factor receptor 2 negative breast cancer.

Breast Cancer Res · 2026 · PMC12918290 · PMID 41572375

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a favorable trendno p-value reported
The combination of imlunestrant and abemaciclib did not demonstrate a confirmed OS benefit (HR 0.82; 95% CI, 0.59–1.16), but a favorable trend was observed [ 12 ].

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