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Multimodal MRI radiomics and deep learning for brain age prediction: age-corrected brain age gap analysis in patients with insomnia.

Biomed Eng Online · 2026 · PMC12918334 · PMID 41507907

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a possible trendno p-value reported
Rather than establishing causality, these results hint at a possible trend in which insomnia-related BAG may be more observable in midlife and older adults.

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a pronounced trendno p-value reported
The insomnia group exhibited a markedly higher predicted brain age compared to chronological age (uncorrected mean BAG = 8.10 years; age-adjusted mean BAG = 1.60 years; both p < 0.001), indicating a pronounced trend of advanced brain aging and accelerated decline.

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