BMI1 represses G-quadruplex DNA formation to maintain genomic stability during replication.

J Biol Chem · 2026 · PMC12919260 · PMID 41570993

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highly significantno p-value reported

When compared to controls, shBMI1 HDFs showed a highly significant R coefficient of 0.58 between G4s and 53BP1, with robust co-localization between G4s and large DNA damage foci ( Fig. 4 A -white arrows).

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