Primed mesenchymal stem cells attenuate schistosomiasis fibrosis by enhancing macrophage subset switching and efferocytosis via Itgb2-Rac1 axis.

Cell Death Discov · 2026 · PMC12920750 · PMID 41667438

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Primed MSCs led to a decrease of Tgfb levels within macrophages compared with control group; CD18 blockade failed to increase Tgfb expression (in spite of an increasing trend), while Rac1 inhibitor NSC23766 could (Fig. 8 ).

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