Barely Significant
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The relationship between methadone dosage and plasma level changes with aging in methadone maintenance treatment (MMT) patients.

Subst Abuse Treat Prev Policy · 2026 · PMC12922290 · PMID 41715212

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a trend toward significanceno p-value reported
When stratified by age and sex groups, a similar pattern was observed (significant for the dose and as a trend toward significance for the plasma levels).

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