Gastrodin inhibits the formation of ataxin-3 aggregates by regulating the level of ERK1/2/P38 proteins.

Orphanet J Rare Dis · 2026 · PMC12922401 · PMID 41715186

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an increasing trendno p-value reported

Consistent with previous reports, compared with DMSO treatment, 10 μM gastrodin treatment increased the antioxidative activity in HEK293T cells, 10 μM and 50 μM gastrodin treatment showed an increasing trend of the antioxidative activity in ataxin-3-15Q-expressing HEK293T cells (Fig. 3 A, B).

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