A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation.

J Exp Med · 2026 · PMC12922663 · PMID 41718717

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0.0005

closest p · 0.0× alpha

0.0005

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The sentences

highly significantP < 0.0005actually significant

Analysis of individual cells in each cluster revealed increased frequencies of cells with highly significant enrichments (P < 0.0005) of response to IFNγ signatures in Pik3cd E1020K/+ lungs, including CD4 T cells (cluster 1), CD8 T cells (cluster 4), neutrophils (cluster 5), macrophage/monocytes (cluster 6), γδ T cells (cluster 8), and B cells (clusters 0 and 2) ( Fig. 1 H and Fig.

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